Development of Small-Molecule MERS-CoV Inhibitors
Identifieur interne : 000A08 ( Main/Exploration ); précédent : 000A07; suivant : 000A09Development of Small-Molecule MERS-CoV Inhibitors
Auteurs : Ruiying Liang ; Lili Wang ; Naru Zhang ; Xiaoqian Deng ; Meng Su ; Yudan Su ; Lanfang Hu ; Chen He ; Tianlei Ying [République populaire de Chine] ; Shibo Jiang [République populaire de Chine] ; Fei YuSource :
- Viruses [ 1999-4915 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (pharmacologie), Bibliothèques de petites molécules (pharmacologie), Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Découverte de médicament, Humains, Infections à coronavirus (traitement médicamenteux), Pandémies (), Réplication virale (), Souris.
- MESH :
- pharmacologie : Antiviraux, Bibliothèques de petites molécules.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient, Découverte de médicament, Humains, Pandémies, Réplication virale, Souris.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (pharmacology), Coronavirus Infections (drug therapy), Drug Discovery, Humans, Mice, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (physiology), Pandemics (prevention & control), Small Molecule Libraries (pharmacology), Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Antiviral Agents, Small Molecule Libraries.
- drug effects : Middle East Respiratory Syndrome Coronavirus, Virus Replication.
- drug therapy : Coronavirus Infections.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- prevention & control : Pandemics.
- Animals, Drug Discovery, Humans, Mice.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.
Url:
DOI: 10.3390/v10120721
PubMed: 30562987
PubMed Central: 6316138
Affiliations:
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Development of Small-Molecule MERS-CoV Inhibitors</title><author><name sortKey="Liang, Ruiying" sort="Liang, Ruiying" uniqKey="Liang R" first="Ruiying" last="Liang">Ruiying Liang</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><affiliation><nlm:aff id="af2-viruses-10-00721">Research Center of Chinese Jujube, Hebei Agricultural University, Baoding 071001, China;<email>yywll@hebau.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name><affiliation><nlm:aff id="af3-viruses-10-00721">Department of Clinical Medicine, Faculty of Medicine, Zhejiang University City College, Hangzhou 310015, China;<email>zhangnr@zucc.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Deng, Xiaoqian" sort="Deng, Xiaoqian" uniqKey="Deng X" first="Xiaoqian" last="Deng">Xiaoqian Deng</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Su, Meng" sort="Su, Meng" uniqKey="Su M" first="Meng" last="Su">Meng Su</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Su, Yudan" sort="Su, Yudan" uniqKey="Su Y" first="Yudan" last="Su">Yudan Su</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> 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Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno 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(R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><affiliation><nlm:aff id="af2-viruses-10-00721">Research Center of Chinese Jujube, Hebei Agricultural University, Baoding 071001, China;<email>yywll@hebau.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name><affiliation><nlm:aff id="af3-viruses-10-00721">Department of Clinical Medicine, Faculty of Medicine, Zhejiang University City College, Hangzhou 310015, China;<email>zhangnr@zucc.edu.cn</email></nlm:aff></affiliation></author><author><name sortKey="Deng, Xiaoqian" sort="Deng, Xiaoqian" uniqKey="Deng X" first="Xiaoqian" last="Deng">Xiaoqian Deng</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Su, Meng" sort="Su, Meng" uniqKey="Su M" first="Meng" last="Su">Meng Su</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Su, Yudan" sort="Su, Yudan" uniqKey="Su Y" first="Yudan" last="Su">Yudan Su</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Hu, Lanfang" sort="Hu, Lanfang" uniqKey="Hu L" first="Lanfang" last="Hu">Lanfang Hu</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="He, Chen" sort="He, Chen" uniqKey="He C" first="Chen" last="He">Chen He</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author><author><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name><affiliation wicri:level="1"><nlm:aff id="af4-viruses-10-00721">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name><affiliation wicri:level="1"><nlm:aff id="af4-viruses-10-00721">Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name><affiliation><nlm:aff id="af1-viruses-10-00721">College of Life and Science, Hebei Agricultural University, Baoding 071001, China;<email>ruiyingliang@outlook.com</email> (R.L.);<email>dengxiaoqian0926@hotmail.com</email> (X.D.);<email>sumeng123@hotmail.com</email> (M.S.);<email>suyudan123@hotmail.com</email> (Y.S.);<email>hlf0519@hotmail.com</email> (L.H.);<email>hechen285@hotmail.com</email> (C.H.)</nlm:aff></affiliation></author></analytic><series><title level="j">Viruses</title><idno type="eISSN">1999-4915</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Coronavirus Infections (drug therapy)</term><term>Drug Discovery</term><term>Humans</term><term>Mice</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Pandemics (prevention & control)</term><term>Small Molecule Libraries (pharmacology)</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Bibliothèques de petites molécules (pharmacologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Découverte de médicament</term><term>Humains</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Pandémies ()</term><term>Réplication virale ()</term><term>Souris</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Small Molecule Libraries</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Bibliothèques de petites molécules</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Pandemics</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Drug Discovery</term><term>Humans</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Découverte de médicament</term><term>Humains</term><term>Pandémies</term><term>Réplication virale</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M. Cotten</name></author><author><name sortKey="Watson, S J" uniqKey="Watson S">S.J. Watson</name></author><author><name sortKey="Zumla, A I" uniqKey="Zumla A">A.I. Zumla</name></author><author><name sortKey="Makhdoom, H Q" uniqKey="Makhdoom H">H.Q. Makhdoom</name></author><author><name sortKey="Palser, A L" uniqKey="Palser A">A.L. Palser</name></author><author><name sortKey="Ong, S H" uniqKey="Ong S">S.H. Ong</name></author><author><name sortKey="Al Rabeeah, A A" uniqKey="Al Rabeeah A">A.A. Al Rabeeah</name></author><author><name sortKey="Alhakeem, R F" uniqKey="Alhakeem R">R.F. 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Katze</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Deng, Xiaoqian" sort="Deng, Xiaoqian" uniqKey="Deng X" first="Xiaoqian" last="Deng">Xiaoqian Deng</name><name sortKey="He, Chen" sort="He, Chen" uniqKey="He C" first="Chen" last="He">Chen He</name><name sortKey="Hu, Lanfang" sort="Hu, Lanfang" uniqKey="Hu L" first="Lanfang" last="Hu">Lanfang Hu</name><name sortKey="Liang, Ruiying" sort="Liang, Ruiying" uniqKey="Liang R" first="Ruiying" last="Liang">Ruiying Liang</name><name sortKey="Su, Meng" sort="Su, Meng" uniqKey="Su M" first="Meng" last="Su">Meng Su</name><name sortKey="Su, Yudan" sort="Su, Yudan" uniqKey="Su Y" first="Yudan" last="Su">Yudan Su</name><name sortKey="Wang, Lili" sort="Wang, Lili" uniqKey="Wang L" first="Lili" last="Wang">Lili Wang</name><name sortKey="Yu, Fei" sort="Yu, Fei" uniqKey="Yu F" first="Fei" last="Yu">Fei Yu</name><name sortKey="Zhang, Naru" sort="Zhang, Naru" uniqKey="Zhang N" first="Naru" last="Zhang">Naru Zhang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Ying, Tianlei" sort="Ying, Tianlei" uniqKey="Ying T" first="Tianlei" last="Ying">Tianlei Ying</name></noRegion><name sortKey="Jiang, Shibo" sort="Jiang, Shibo" uniqKey="Jiang S" first="Shibo" last="Jiang">Shibo Jiang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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